Product name:Nafcillin acid

CAS:147-52-4

Molecular formula:C21H22N2O5S

Molecular weight:414.476

Appearance:white or yellowish crystalline powder

Usage: The intermediate of Naficillin sodium

Product description:Nafcillin acid is a narrow-spectrum beta-lactam antibiotic of the penicillin class. As a beta-lactamase-resistant penicillin, it is used to treat infections caused by Gram-positive bacteria, in particular, species of staphylococci that are resistant to other penicillins.

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Some applications of Mycophenolate Mofetil

Mycophenolate mofetil (MMF) (brand name CellCept, analyze with Myfortic - natrii mycophenolas) is an immunosuppressant and prodrug of mycophenolic acid, acclimated abundantly in displace medicine. It is a capricious inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine (guanine) biosynthesis which is all-important for the advance of T beef and B cells. Other beef are able to balance purines via a abstracted scavenger alleyway and are appropriately able to escape the effect.
MMF is aswell acclimated in the analysis of autoimmune diseases, such as Behçet's disease, pemphigus vulgaris, systemic lupus erythematosus and adverse abridged lupus erythematosus. Suppressing T beef and B beef stops them from advancing advantageous cells, but aswell weakens their adeptness to avert adjoin infections.
MMF became accepted as a beneath baneful alternative, instead of or in accession to azathioprine and cyclophosphamide.
The actinic name for mycophenolate mofetil is 2-morpholinoethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate. Its empiric blueprint is C23H31NO7 and atomic weight 433.50. Mycophenolate mofetil is morpholinoethyl ester of mycophenolic acid, which is acclimated to affectation the carboxyl group. Mycophenolate mofetil is appear to accept pKa ethics 5.6 for the morpholino atom and 8.5 for the phenolic group.


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From:Lactic acid bacteria

Hydrogen production by GH - 596 metal catalysts basic information

Name:Hydrogen production by GH - 596 metal catalysts
Proportion of pile:0.60
Particle size:Φ1.5-2.0
The Surface area(m2/g)：150~200
Appearance:Atts grey sphere particles
Palladium metal content（wt%):0.30


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From:Catalyst chemistry

Lumiracoxib for lung cancer research

Explore Lumiracoxib may induce cancer cell apoptosis mechanism. Methods: The human lung cancer cell line A549 and NCI  H460 cells were added to a final concentration of IL-1β1 1 μg / L stimulated 24 h, then added different concentrations Lumiracoxib cultured 24 h, using the Western blot assay ERK2, p-ERK and Bcl-2 expression levels. Lumiracoxib vitro processing A549, NCI-H460, the use by Western blot Bcl-2, Bax expression levels. Results: Lumiracoxib role in lung cancer cells after ERK2 and p-ERK phosphorylation levels were decreased, accompanied by decreased levels of Bcl-2, the difference was statistically significant (P <0.01). And with Lumiracoxib concentration increased, Bcl-2 protein expression was decreased, while Bax protein expression in A549 cells enhanced in NCI-H460 cells unchanged, Bcl-2/Bax ratio decreased. Conclusion: Lumiracoxib induce apoptosis in lung cancer cells may be related through the ERK signal transduction pathway in lung cancer cells to produce Bcl-2, thereby inducing Bcl-2/Bax ratio decline.


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From:pharmaceutical chemicals