Mycophenolate mofetil (MMF) (brand name CellCept, analyze with Myfortic - natrii mycophenolas) is an immunosuppressant and prodrug of mycophenolic acid, acclimated abundantly in displace medicine. It is a capricious inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine (guanine) biosynthesis which is all-important for the advance of T beef and B cells. Other beef are able to balance purines via a abstracted scavenger alleyway and are appropriately able to escape the effect.
MMF is aswell acclimated in the analysis of autoimmune diseases, such as Behçet's disease, pemphigus vulgaris, systemic lupus erythematosus and adverse abridged lupus erythematosus. Suppressing T beef and B beef stops them from advancing advantageous cells, but aswell weakens their adeptness to avert adjoin infections.
MMF became accepted as a beneath baneful alternative, instead of or in accession to azathioprine and cyclophosphamide.
The actinic name for mycophenolate mofetil is 2-morpholinoethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate. Its empiric blueprint is C23H31NO7 and atomic weight 433.50. Mycophenolate mofetil is morpholinoethyl ester of mycophenolic acid, which is acclimated to affectation the carboxyl group. Mycophenolate mofetil is appear to accept pKa ethics 5.6 for the morpholino atom and 8.5 for the phenolic group.
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From:Lactic acid bacteria
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