Sibutramine is rapidly captivated from the
gastro-intestinal amplitude and is aboriginal metabolised in the alarmist to
DMS and DDMS, with a half-life of 1.1 hours. Peak claret concentrations of the
metabolites are accomplished aural 3-4 hours, and all-embracing it has been
bent that 77% of a individual dosage of sibutramine is captivated by the body.
Sibutramine is primarily metabolised by the cytochrome
P450(3A4) enzyme. DMS and DDMS are aswell metabolised by the alarmist by
hydroxylation and alliance to pharmcologically abeyant forms, which are again
excreted from the body. The abolishment bisected activity of DMS is 16 hours
and the abolishment half-life of DDMS is 14 hours.
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