Clioquinol Subacute myelo-optic neuropathy

Clioquinol's use as an antiprotozoal biologic has been belted or discontinued in some countries due to an accident in Japan area over 10,000 humans developed subacute myelo-optic neuropathy (SMON) amid 1957 and 1970. The biologic was used broadly in abounding countries afore and afterwards the SMON accident after agnate reports.

As yet, no account exists as to why it produced this reaction, and some advisers accept questioned whether clioquinol was the adroit abettor in the disease, acquainted that the biologic had been used for 20 years above-mentioned to the catching after incident, and that the SMON cases began to abate in amount above-mentioned to the cessation of the drug.Theories appropriate accept included abnormal dosing, the acceptable use of the biologic for continued periods of time, and dosing which did not accede the abate boilerplate ability of Japanese; about a dosage barnacle accord amid SMON development and clioquinol use was never found, suggesting the alternation of addition compound. Advisers accept aswell appropriate the SMON catching could accept been due to a viral infection with an Inoue-Melnick virus.