Elvitegravir interactions and contraindications

Elvitegravir is a biologic used for antiviral analysis adjoin HIV. It is bogus by Gilead.

Elvitegravir is the additional “integrase inhibitor” drug. If HIV infects a cell, it combines its abiogenetic cipher into the cell's own code. This is crystalline in actuality area 400, footfall 5. Elvitegravir blocks this process. If elvitegravir blocks integration, HIV infects a corpuscle but cannot accomplish added copies of itself.

Elvitegravir is metabolised via the alarmist agitator CYP3A. Substances that abet this agitator can abate elvitegravir concentrations in the body, potentially triggering the development of aggressive virus strains. Consequently, co-administration of able CYP3A inducers is contraindicated; examples are rifampicin, the anticonvulsants carbamazepine, phenobarbital and phenytoin, as able-bodied as St John's wort.

Glucuronidation of elvitegravir is facilitated by the enzymes UGT1A1 and 3, consistent in added blood blood levels if taken calm with able UGT1A inhibitors such as ritonavir and added HIV protease inhibitors.

Furthermore, elvitegravir is a anemic to average inducer of CYP1A2, CYP2C19, CYP2C9, CYP3A, and a amount of UGTs; the analytic appliance of these allegation is about unclear.