Anti-Cyclin G contains a archetypal N terminal cyclin box and a carboxy terminal area arrangement akin to the tyrosine phosphorylation website of the epidermal advance agency receptor. Cyclin G2 shares 53% amino acerbic arrangement character with cyclin G1. Peak announcement of cyclin G2 is apparent in backward S phase, as against to cyclin G1 expression, which is constitutive.
Cyclin G1 may play a role in advance regulation. It is associated with G2/M appearance arrest in acknowledgment to DNA damage. It may be an average by which p53 mediates its role as an inhibitor of cellular proliferation.
Synthetic peptide conjugated to KLH, agnate to a arena aural centralized arrangement amino acids 214-243 of Human Cyclin G2 (NP_004345.1).
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