Histones are the proteins carefully associated with DNA molecules. They are amenable for the anatomy of chromatin and play important roles in the adjustment of gene expression. Five types of histones accept been identified: H1 (or H5), H2A, H2B, H3 and H4. H1 and its akin protein H5 are complex in higher-order structures of chromatin. The added four types of histones accessory with DNA to anatomy nucleosomes. H1 (or H5) has about 220 residues. Added types of histones are smaller, anniversary consisting of 100-150 residues.
Anti-Histone H1b(Histone H1.4) shows a replication dependent expression. Its gene is present in cluster 1 on chromosome number 6 and its mRNA is not polyadenylated (PMID: 19587527). It has been reported that around 25% of H1.4 is specifically methylated on K25 (reported as H1K26) in human tissues (PMID: 19552482). Phophorylated serine 186 (reported as H1S187) of histone H1.4 variant is specifically associated with ribosomal gene promoters that are transcriptionally active (PMID: 20439994). Histone H1.4 expression is increased during early apoptosis (PMID: 9882631). A recent report classifies it as a strong condenser of chromatin (PMID: 19794910).
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Elisa assay kits
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