Fluconazole Description

Fluconazole, a constructed antifungal abettor of the imidazole class, is used to amusement vaginal candidiasis. It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the accumulation of ergosterol which is an capital basic in the fungal corpuscle membrane.

Fluconazole interacts with 14-α demethylase, a cytochrome P-450 agitator all-important to catechumen lanosterol to ergosterol. As ergosterol is an capital basic of the fungal corpuscle membrane, inhibition of its amalgam after-effects in added cellular permeability causing arising of cellular contents. Fluconazole may aswell arrest autogenous respiration, collaborate with film phospholipids, arrest the transformation of yeasts to mycelial forms, arrest purine uptake, and blemish triglyceride and/or phospholipid biosynthesis.