Pipotiazine Description

Pipotiazine has accomplishments agnate to those of added phenothiazines. Among the altered phenothiazine derivatives, it appears to be beneath sedating and to accept a anemic ability for causing hypotension or potentiating the furnishings of CNS depressants and anesthetics. However, it produces a top accident of added cone-shaped reactions. It is acclimated for the aliment analysis of abiding non-agitated schizophrenic patients. Affection of balance cover astringent extrapyramidal manifestations, hypotension, apathy and sedation.

Pipotiazine has accomplishments agnate to those of added phenothiazines. Among the altered phenothiazine derivatives, it appears to be beneath sedating and to accept a anemic ability for causing hypotension or potentiating the furnishings of CNS depressants and anesthetics. However, it produces a top accident of added cone-shaped reactions. It reduces activity of dopamine receptors in the limbic system. Its 5-HT animosity helps adapt dopamine activity in the cortical regions.

Pipotiazine acts as an adversary (blocking agent) on altered postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - altered antipsychotic backdrop on advantageous and bootless symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive backdrop as able-bodied as an abrasion of extrapypramidal side-effects, but aswell arch to weight gain, abatement in claret pressure, balance and acclamation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, abatement in claret burden and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, blurred of claret pressure, reflex tachycardia, vertigo, sedation, hypersalivation and bender as able-bodied as animal dysfunction, but may aswell abate pseudoparkinsonism - controversial) and assuredly on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic affection like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, atrium tachycardia, ECG-changes and accident of memory, but the anticholinergic activity may abate extrapyramidal side-effects).