Doxepin is acclimated for the analysis of
abasement and/or anxiety. It can aswell be acclimated for abiding urticaria and
in the administration of pain.
Pharmacodynamics
Doxepin, a tricyclic antidepressant of the
dibenzoxepin type, is acclimated to amusement abasement and all-overs and,
topically, pruritus associated with eczema. Doxepin has abundant
anticholinergic and allaying effects. The E (trans)-isomer is added alive as a
serotonin reuptake inhibitor while the Z-isomer acts as a sedative.
Mechanism of action
The apparatus of activity of doxepin is not
absolutely understood. It is anticipation that like amitriptyline, doxepin
enhances the accomplishments of norepinephrine and serotonin by blocking their
reuptake at the neuronal membrane. However, doxepin abominably inhibits the
reuptake of dopamine. Doxepin may aswell act on histamine H1-receptors,
consistent in allaying effects, and β-adrenergic receptors. It is aswell an
adversary of 5-hydroxytryptamine (serotonin) receptors, alpha-1 adrenergic
receptor, and muscarinic cholinergic receptors.
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