Thiazolidine is a heterocyclic amoebic
admixture with a 5-membered saturated ring with a thioether accumulation and an
amine accumulation in the 1 and 3 positions, respectively. It is a sulfur
analog of oxazolidine.
Derivatives, about referred to as
thiazolidines, are known. For example, the biologic pioglitazone contains a
thiazolidine ring. It is a biologic usually adumbrated in cases of blazon II
diabetes for abbreviating claret sugar. It aswell decreases triglycerides and
C-reactive protein levels. It lowers claret burden and increases levels of HDL.
Another biologic which contains a thiazolidine ring is the antibacterial
biologic penicillin.
Thiazolidines may be actinic by a abstract
acknowledgment amid a thiol and an aldehyde or ketone. The acknowledgment is
reversible. Therefore, abounding thiazolidines are labile appear hydrolysis in
aqueous solution. Hydrolysis of the thiazolidine generates the thiol and
aldehyde or ketone from which it was synthesized.
Thiazolidine with 2 ketones (at the 2 and 4
positions) provides the anatomic accumulation of the thiazolidinediones.
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