CAS:
144-48-9
Molecular
Formula: C2H4INO
Molecular
Weight: 184.96
Iodoacetamide
is an alkylating sulfhydryl reagent. Its accomplishments are affiliated to
those of iodoacetate.
Iodoacetamide
is an irreversible inhibitor of all cysteine peptidases, with the accoutrement
of inhibition occurring from alkylation of the catalytic cysteine antithesis
(see schematic). In apologue with its acid derivative, iodoacetate,
iodoacetamide reacts about added quickly. This analysis appears adverse to
accustomed actinic reactivity, about the appearance of a favourable alternation
amidst the complete imidazolium ion of the catalytic histidine and the abnormally
accountable carboxyl-group of the iodoacetate is the accuracy for the added
about activity of iodoacetamide.
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